Regulators of regulatory pathway: Biofilm formation - Escherichia coli

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0071 experimental Z4049 (RpoS) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 3654380..3655372 (-) 446003635 Z1921 (KatN) (↓)
REG0190 experimental ypk_3425 (RpoS) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3759239..3760237 (-) 499505140 T6SS-4 promoter region (↓)
REG0206 experimental ETAE_2873 (RpoS) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3025094..3026080 (-) 502612732 ETAE_0886 (esrB) promoter (↑)
REG0346 experimental BN49_RS06445 (rpoS) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1060243..1061235 (+) 489004494 TssB transcription (↓)
REG0364 experimental Y113_RS11250 (RpoS) T6SS00791 experimental protein Transcription regulator Edwardsiella tarda PPD130/91 chromosome (NZ_JACQ01000026) 9122..10108 (-) 502612732 EvpQ transcription and protein level (↑)
REG0011 experimental Y880_05180 (rmsF) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5147809..5148024 (-) 489186811 tssA1 expression (↑)
REG0041 experimental PA5183a (RsmN) T6SS00003 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5836470..5836685 (-) 554753081 FHA (PA0081) (↑); PA3487 (pldA) expression (↑)
REG0102 experimental VP_RS12395 (CsrA) T6SS00043 experimental; T6SS00044 experimental protein carbon storage regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2688313..2688510 (-) 490550575 Hcp and vgrG expression and secretion (↓)
REG0158 experimental PA14_52570 (RsmA) T6SS00150 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4660393..4660578 (-) 489176459 RSMF (↑); tssA1 RNA (↑); RSMA (↑)
REG0193 experimental YPK_3372 (CsrA) T6SS00260 experimental protein carbon storage regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3698608..3698793 (-) 169752121 YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0030 experimental GPY04_RS13825 (QstR) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2994333..2994977 (-) 447111060 Unknown (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0072 experimental Z5519 (OxyR) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 5033893..5034810 (+) 446948683 Z1921 (KatN) (↓)
REG0153 experimental BTH_I1281 (OxyR) T6SS00114 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 1432632..1433591 (+) 497575020 BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0189 experimental YPK_4079 (OxyR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4502978..4503895 (-) 488138270 T6SS-4 promoter region (↓)
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0185 experimental YpsIP31758_3980 (ompR) T6SS00225 experimental protein TCS-RR Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 4465260..4465979 (-) 490527984 T6SS-4 promoter (↓)
REG0199 experimental YPK_RS00840 (OmpR) T6SS00260 experimental protein TCS-RR Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 223260..223979 (+) 488137706 T6SS4 promoter (↓)
REG0003 experimental RT90_01105 (rcsC) T6SS01264 experimental protein TCS-HK Serratia marcescens strain RM66262 chromosome (JWLO01000001) 232638..235499 (+) 735006326 RT90_01115 (rcsB) (↑)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0004 experimental RT90_01115 (rcsB) T6SS01264 experimental protein TCS-RR Serratia marcescens strain RM66262 chromosome (JWLO01000001) 235561..236211 (-) 735006328 vgrG promoter (↓)
REG0341 experimental BN49_RS21260 (rcsB) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 4066268..4066918 (+) 489002368 phoPQ (↑)
REG0362 experimental PPECC33_RS11945 (rcsB) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2429320..2429970 (+) 446984661 T6SS transcription (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0235 experimental ETAE_1562 T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1668753..1670378 (-) 780104675 ETAE_0886 (esrB) promoter (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0071 experimental Z4049 (RpoS) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 3654380..3655372 (-) 446003635 Z1921 (KatN) (↓)
REG0190 experimental ypk_3425 (RpoS) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3759239..3760237 (-) 499505140 T6SS-4 promoter region (↓)
REG0206 experimental ETAE_2873 (RpoS) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3025094..3026080 (-) 502612732 ETAE_0886 (esrB) promoter (↑)
REG0346 experimental BN49_RS06445 (rpoS) T6SS01214 experimental protein Global regulator Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 1060243..1061235 (+) 489004494 TssB transcription (↓)
REG0364 experimental Y113_RS11250 (RpoS) T6SS00791 experimental protein Transcription regulator Edwardsiella tarda PPD130/91 chromosome (NZ_JACQ01000026) 9122..10108 (-) 502612732 EvpQ transcription and protein level (↑)
REG0011 experimental Y880_05180 (rmsF) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 5147809..5148024 (-) 489186811 tssA1 expression (↑)
REG0041 experimental PA5183a (RsmN) T6SS00003 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 5836470..5836685 (-) 554753081 FHA (PA0081) (↑); PA3487 (pldA) expression (↑)
REG0102 experimental VP_RS12395 (CsrA) T6SS00043 experimental; T6SS00044 experimental protein carbon storage regulatory pathway Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2688313..2688510 (-) 490550575 Hcp and vgrG expression and secretion (↓)
REG0158 experimental PA14_52570 (RsmA) T6SS00150 experimental protein RsmA regulatory pathway Pseudomonas aeruginosa UCBPP-PA14 chromosome (NC_008463) 4660393..4660578 (-) 489176459 RSMF (↑); tssA1 RNA (↑); RSMA (↑)
REG0193 experimental YPK_3372 (CsrA) T6SS00260 experimental protein carbon storage regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3698608..3698793 (-) 169752121 YPK_3567 (RovC) (↑); YPK_3563 transcript (↑)
REG0030 experimental GPY04_RS13825 (QstR) T6SS01168 experimental protein Global regulator Vibrio cholerae C6706 chromosome (NZ_CP046844) 2994333..2994977 (-) 447111060 Unknown (↓)
REG0303 experimental VCA1552_00154 (QstR) T6SS01112 experimental protein c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 149920..150564 (-) 447111060 TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0072 experimental Z5519 (OxyR) T6SS00006 insolico protein Global regulator Escherichia coli O157:H7 str. EDL933 chromosome (NC_002655) 5033893..5034810 (+) 446948683 Z1921 (KatN) (↓)
REG0153 experimental BTH_I1281 (OxyR) T6SS00114 experimental protein Global regulator Burkholderia thailandensis E264 chromosome (NC_007651) 1432632..1433591 (+) 497575020 BTH_RS09735 (T6SS-4) Promotor,−536 to −186 relative to the ATG start codon (↑)
REG0189 experimental YPK_4079 (OxyR) T6SS00260 experimental protein Global regulator Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 4502978..4503895 (-) 488138270 T6SS-4 promoter region (↓)
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0185 experimental YpsIP31758_3980 (ompR) T6SS00225 experimental protein TCS-RR Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 4465260..4465979 (-) 490527984 T6SS-4 promoter (↓)
REG0199 experimental YPK_RS00840 (OmpR) T6SS00260 experimental protein TCS-RR Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 223260..223979 (+) 488137706 T6SS4 promoter (↓)
REG0003 experimental RT90_01105 (rcsC) T6SS01264 experimental protein TCS-HK Serratia marcescens strain RM66262 chromosome (JWLO01000001) 232638..235499 (+) 735006326 RT90_01115 (rcsB) (↑)
REG0100 experimental VP_RS12495 (barA) T6SS00043 experimental; T6SS00044 experimental protein TCS-HK Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2712492..2715290 (+) 491625032 Hcp expression and secretion (↓)
REG0150 experimental Psyr_3698 (gacS) T6SS00086 experimental protein TCS-HK Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4385550..4388303 (+) 499587812 T6SS transcription (↓)
REG0330 experimental Pchl3084_4333 (gacS) T6SS01266 insolico; T6SS01267 insolico protein TCS-RR Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 5113748..5116501 (+) 496335944 Pchl3084_3491 (gacA) (↓)
REG0351 experimental PSEBR_RS22825 (GacS) T6SS00431 insolico; T6SS00432 insolico protein TCS-RR Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome (NC_015379) 5188012..5190762 (+) 503459407 hcp1 transcript (↓); hcp2 transcript (↓)
REG0004 experimental RT90_01115 (rcsB) T6SS01264 experimental protein TCS-RR Serratia marcescens strain RM66262 chromosome (JWLO01000001) 235561..236211 (-) 735006328 vgrG promoter (↓)
REG0341 experimental BN49_RS21260 (rcsB) T6SS01214 experimental protein TCS-RR Klebsiella pneumoniae strain Kp52.145 chromosome (NZ_FO834906) 4066268..4066918 (+) 489002368 phoPQ (↑)
REG0362 experimental PPECC33_RS11945 (rcsB) T6SS01034 experimental protein TCS-RR Escherichia coli PCN033 chromosome (NZ_CP006632) 2429320..2429970 (+) 446984661 T6SS transcription (↓)
REG0012 experimental Y880_02189 (gacA/uvrY) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS-RR Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 2199690..2200334 (-) 510933056 hcp expression (↓)
REG0044 experimental PA2586 (gacA) T6SS00003 experimental protein TCS-RR Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 2925788..2926432 (-) 15597782 hcp1 (PA0085) expression and secretion (↓)
REG0091 experimental PFL_RS17995 (gacA/uvrY/SirA) T6SS00035 experimental protein TCS-RR Pseudomonas protegens Pf-5 chromosome (NC_004129) 4110513..4111154 (-) 499374263 T6SS transcripts (↓)
REG0101 experimental VP_RS09470 (UvrY) T6SS00043 experimental; T6SS00044 experimental protein TCS-RR Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2037468..2038112 (-) 491529158 CsrB (↓)
REG0253 experimental PAM18_RS12360 (gacA) T6SS00612 insolico; T6SS00613 insolico; T6SS00611 insolico protein TCS-RR Pseudomonas aeruginosa M18 chromosome (NC_017548) 2625815..2626459 (+) 489180874 hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓)
REG0331 experimental Pchl3084_3491 (gacA) T6SS01266 insolico; T6SS01267 insolico protein TCS-HK Pseudomonas chlororaphis subsp. aureofaciens 30-84 chromosome (NZ_CM001559) 4134794..4135435 (-) 496335231 Pchl3084_5419 (rsmY)promotor (↓); Pchl3084_1190 (rsmZ)promotor (↓); Pchl3084_1189 (rpoS)transcript (↓)
REG0067 experimental PA3477 (RhlR) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889925..3890650 (-) 15598673 T6SS transcript (↓)
REG0301 experimental VCA1552_RS12025 (crp) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2558371..2559003 (+) 446164894 Hcp expression and secretion (↓)
REG0235 experimental ETAE_1562 T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1668753..1670378 (-) 780104675 ETAE_0886 (esrB) promoter (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)